This may be the root cause of SD/eczema
OK, try taking over the counter statins (Zocor in
Europe, Lipitor in the USA), the cholesterol lowering
drug(1 per day) and pantethine(300-1200mg per day,
from a health store). Not for the cholesterol lowring
effect but for the effect on blocking adrenaline and
noradrenaline. In Europe at least simvastatin is OTC
in USA I am not sure, else show your doc the
supporting evidence and ask him to try you on it.
If you are interested on why, then read the very
technical pdf doc downloadable link below. You may
want to go straight to page 36 to get the conclusion,
and note the abbreviations listed on page 2.
It is based on the fact that catecholamines(adrenaline
and noradrenaline) are raised in allergies, due to
overaction of the part of the nervous system called
the sympathetic system and this causes so-called TH2
inflammation. The aim is to dampen this system down.
Also don’t drink any tea(green or black) it raises
noradrenaline and chocolate and caffeine acts as a
surrogate noradrenaline, so avoid.
The statins damp the sympathetic nervous system and
lower noradrenaline :
(Apparantly melatonin also dampens the adrenalines.
3mg at bedtime, although I find the statins and
pantethine work the best)
Pantethine. This is a derivative of pantothenic acid,
and has
long been known to alleviate allergies and normalize
blood fats. It also
reduces noradrenaline and this may be the mechanism of
its action on
allergies and the TH2 inflammations ? In turn the
pantethine matabolite
Cysteamine is even more potent, by this account.
Central Nervous System Impact of Pantethine
Cysteamine, a cysteine derivative formed from the
degradation of pantethine,
is known to cause depletion of somatostatin,
prolactin, and noradrenaline in
the brain and peripheral tissues. Similarly,
pantethine has been shown to
deplete somatostatin, prolactin, and noradrenaline,
although with lower
efficacy compared to cysteamine.33 The actual clinical
relevance of
pantethine’s impact on the central nervous system in
humans has not been
explored. In animals, the effect on somatostatin,
prolactin, and
noradrenaline has been demonstrated following
intraperitoneal and
intravenous administration of pantethine; however, the
effect does not
appear to occur after an oral dose.
Ong et al reported intraperitoneal injection of
pantethine depleted
somatostatin and prolactin levels in experimental
animals.34 Vecsei et al
also observed decreased concentrations of striatal
somatostatin following
administration of high doses (1.95-3.90 mM/kg SC) of
pantethine. This effect
was attenuated 24 hours after treatment.35 Both
intraperitoneal and
intravenous administration of pantethine can deplete
prolactin from plasma;
however, oral administration of pantethine does not
seem to be capable of
influencing plasma prolactin concentrations.36
The effects of pantethine on central
neurotransmissions was investigated in
rats. Pantethine administered in low doses (0.48-0.96
mM/kg SC) induced a
decrease of the hypothalamic noradrenaline level
without influencing the
concentrations of dopamine and dihydroxyphenyl acetic
acid (DOPAC). When
pantethine was injected in higher doses (1.95-3.90
mM/kg SC), a marked
depression of noradrenaline and an increased
concentration of dopamine and
DOPAC was observed in the hypothalamus. This effect
was attenuated 12 hours
following administration of pantethine, and
disappeared after 24 hours.35
While pantethine consistently reduces the
noradrenaline and increases the
dopamine and DOPAC concentrations in the
hypothalamus,37,38 pantothenic acid
does not appear to influence hypothalamic
catecholamine concentrations.38
October 12th, 2005 at 7:08 am
What about decaf tea and coffee?
October 12th, 2005 at 3:28 pm
Tea is no good, even green tea. It stops adrenaline
and noradrenaline getting processed by enzymes. Tea
blocks the enzymes, with or without caffeine. This is
fine if you are fat and TH1 dominent, but is not so
good if you are TH2 dominent as it increases the
inflammation associated with TH2.
Caffeine acts as a stimulant and increases adrenaline
by increasing its production.
"Green Tea also has a thermogenic fat burning effect.
This is achieved by increasing the half-life of
noradrenaline by
inhibiting the enzyme catechol O-methyltransferase
(COMT), which is responsible for the breakdown of
extracellular noradrenaline."
BTW : I found a guy who attacked his rosacea from the
adrenaline nervous system aspect and claims good
success.
Although he has a very complicated protocol, I believe
from the last email I sent that the sypathetic nervous
system and the constant raised "flight or fight"
adrenaline causes havoc with the skin and other
organs.
This is a FAR from exhaustive list :
Things that will slow down the sympathetic nervous
system(want more of these) :
magnesium
beta-blockers
statin cholesterol drugs
pantethine
low dose cortisol(hydrocortisone)
herbs : skullcap, nettles and others
moderate exercise
meditation/yoga
Things that will stimulate the sympathetic nervous
system(want to avoid these) :
Caffeine
tea (green or black)
chocolate
lack of sleep
etc
Google the subject and there is loads of info.
Here is a short layman explanation of adrenaline
causing acne and rosacea , both seborrheic disorders.
Adrenaline flushing - This kind of vascular dilation
is caused by an adrenaline rush. This type of flushing
is the same as systemic flushing, but it is hormone
released. Stress is the body’s reaction to a perceived
threat. Adrenaline and hormones are released, and the
nervous system is activated, sharpening our senses,
but simultaneously our pulse rises, our muscles tense
and our immune system begins to shut down.
——————————
Adrenaline activity can also cause acne in both "men
and women" as a reaction to mental stress or physical
stress. In women, testosterone is produced by the
ovaries with the other half of testosterone in women
being produced by the adrenal glands. Obviously,
estrogen smoothes out the testosterone produced by the
ovaries, but when the estrogen level drops several
days before the menstrual periods, sometimes resulting
acne occurs especially when the adrenal glands over
produce due to stress or fatigue. The adrenal glands
can be stressed continually in both men and women
resulting in too much testosterone with the resulting
over stimulation of the sebaceous glands. Similarly,
in the male an over abundance of testicular
testosterone especially with overly stimulated adrenal
glands causes the overly stimulated sebaceous glands.
Quite often more stress is placed on the adult after
puberty resulting in over active sebaceous glands.
While we can not produce more estrogen to level out
the testosterone, we can drink much more water which
will help relieve stress and assist both acne and
rosacea. Getting enough sleep and finding ways to
relax will help relieve stress and reduce the
adrenaline reaction that follows.
Exercise flushing is caused by the cardiovascular
system pumping harder and faster due to exercise with
the result being vascular dilation. The key is to
minimize vascular dilation while exercising.
Exercise should be done moderately in a cool area
keeping the body well hydrated with water to minimize
the redness. It’s best to adapt slowly over time to
the exercise so that the body is aerobic (with oxygen)
instead of anaerobic (without oxygen causing redness).
Therefore, you can handle more vigorous exercise as
your exercise training increases. Better
cardiovascular shape and exercise means more oxygen in
the blood and more oxygen in blood constricts vessels.