Even more on itraconazole
Key issues Itraconazole is an established, broad-spectrum antifungal
agent with documented in vivo activity against dermatophytes, yeasts
and moulds and an excellent safety profile. Itraconazole tends to
accumulate in keratinous tissues and organs often involved in fungal
infections, such as the lungs. Full exploitation of this
pharmacokinetic profile has led to the development of pulse treatment
regimens that allow similar efficacy with lower overall drug exposure
as well as a reduction in treatment costs. Due to its anti-
inflammatory properties, itraconazole is emerging as the treatment of
choice in inflammatory skin conditions that otherwise have a high
relapse rate, such as seborrheic dermatitis and atopic dermatitis of
the face. Development of new oral liquid and intravenous formulations
has extended the application of itraconazole to systemic fungal
infections, both as standard treatment and as prophylactic and
empiric treatment in immunocompromised hosts.