Seborrheic Dermatitis

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Lithium gluconate in the treatment of seborrhoeic dermatitis: a
multicenter, randomised, double-blind study versus placebo
European Journal of Dermatology. Vol. 12, Issue 6, November -
December 2002: 549-52, Therapy

Summary: Seborrhoeic dermatitis is a frequent and chronic dermatitis
of the face for which the 2 main treatments used are topical
antifungals and corticosteroids. The aim of this study was to
investigate the effect of topical lithium gluconate in the treatment
of this affection.

One hundred and twenty-nine patients with a facial seborrhoeic
dermatitis for at least two months and presenting erythema and

desquamation of moderate to severe intensity, were randomised to
either lithium gluconate ointment dosed at 8% or placebo. The
products were applied twice a day for eight weeks. The primary
endpoint was to obtain a complete remission.

One hundred and twenty-three patients were valid for efficacy
analysis. Lithium gluconate ointment was significantly more
effective than placebo, with a complete clinical remission after 4
and 8 weeks respectively of 11.3% and 29.1% of the patients in the
lithium group, and 5.1% and 3.8% respectively in the placebo group.

This study confirms the effectiveness of 8% lithium gluconate
ointment in the treatment of seborrhoeic dermatitis.

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